Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation.

Maybury-Lewis, Sun Y; Webb, Ashley E · Cell Stem Cell · 2020

editorial · Level V

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Abstract

Asymmetric partitioning of damaged proteins is thought to play a key role in preserving stem cell function with age. In this issue of Cell Stem Cell, Morrow et al. (2020) show that vimentin recruits proteasome machinery to aggresomes to control NSC proteostasis during quiescence exit.

Medical subject headings