Chiral Cu<sub>x</sub> OS@ZIF-8 Nanostructures for Ultrasensitive Quantification of Hydrogen Sulfide In Vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32250001.
- Also identified by DOI 10.1002/adma.201906580.
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Abstract
In this study, a Cu<sub>x</sub> OS@ZIF-8 nanostructure is fabricated to quantify the levels of hydrogen sulfide (H<sub>2</sub> S) in living cells and in vivo. Zeolitic lmidazolate framework-8 (ZIF-8) is chosen as an encapsulation shell to improve the selectivity of this probe. Using this unique nanostructure, ultrasensitive quantification and bioimaging of H<sub>2</sub> S in living cells are successfully achieved. The lower limit of detection is 0.8 and 5.3 nmol per 10<sup>6</sup> cells for circular dichroism and fluorescence modes, respectively. It is found that the chiral Cu<sub>x</sub> OS NPs transformed into achiral Cu<sub>x</sub> S NPs contribute to the ultrasensitive detection. Notably, this probe can also be carried out to detect and track H<sub>2</sub> S levels in tumor-bearing animals. The discoveries put forward for the creation of a detection platform for quantitative tracking and analysis in clinic.
Medical subject headings
- Copper
- Hydrogen Sulfide
- Limit of Detection
- Nanostructures
- Zeolites