NADH Ties One-Carbon Metabolism to Cellular Respiration.
Where this comes from
- Record sourced from PubMed, PMID 32268110.
- Also identified by DOI 10.1016/j.cmet.2020.03.012.
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Abstract
In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.
Medical subject headings
- NAD
- Serine