Why Warburg Works: Lactate Controls Immune Evasion through GPR81.
Level V
Where this comes from
- Record sourced from PubMed, PMID 32268113.
- Also identified by DOI 10.1016/j.cmet.2020.03.001.
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Abstract
Lactate accumulation in tumors-a hallmark of the Warburg effect-has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells.
Medical subject headings
- Breast Neoplasms
- Tumor Microenvironment