Robust method to create a standardized and reproducible atrophic non-union model in a rat femur.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32273661.
- Also identified by DOI 10.1016/j.jor.2020.03.040 and PMC identifier 7132052.
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Abstract
No evidence exists about which biological approach is more reliable for creating non-union model. We investigated how to create a reproducible atrophic non-union model in a rat femur. We compared three groups: simple osteotomy (group A), partial periosteum cauterization (group B), and extensive periosteum and bone marrow resection (group C). All samples in group C demonstrated atrophic non-union in radiological, histological, and biomechanical analyses, however half of the samples in group B showed fracture healing at week 16. Extensive resection of periosteum and bone marrow is important for a reproducible atrophic non-union model in a rat femur.
Anatomy
- femur