Clinical features, prognostic factors and outcome in a series of 29 extra-skeletal Ewing Sarcoma. Adequate margins and surgery-radiotherapy association improve overall survival.

Muratori, Francesco; Mondanelli, Nicola; Pelagatti, Lorenzo; Frenos, Filippo; Matera, Davide; Beltrami, Giovanni; Innocenti, Matteo; Capanna, Rodolfo et al. · J Orthop · 2020

retrospective_cohort · Level III

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Also identified by DOI 10.1016/j.jor.2020.03.018 and PMC identifier 7132112.
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Abstract

Authors review a series of 29 extra-skeletal Ewing Sarcoma (EES). They analyzed characteristics, prognostic factors and outcome of EES. Authors report 60% Overall Survival (OS) and 56% of Event Free Survival (EFS) at 5 years. Better 5 years EFS was found in patients with localized disease (68.8%) compared to metastatic EES (33.3%) (p = 0.042). Radiotherapy + surgery offered the best local treatment (p=0.017). Volume (p = 0.032), Surgical margins (p = 0.01), metastatic disease (p = 0.0013) were a significant prognostic factor for OS at 5-yrs. Adequate margins and surgery+radiotherapy improve Overall Survival.

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