Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32284552.
- Also identified by DOI 10.1038/s41551-020-0539-4 and PMC identifier 7422941.
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Abstract
Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, pathological metabolic shifts, fibrosis and calcium handling) at the transcriptomic, structural and functional levels. We also show that the organoids can model hypoxia-enhanced doxorubicin cardiotoxicity. Human organoids that model diseases with non-genetic pathological factors could help with drug screening and development.
Medical subject headings
- Drug Evaluation, Preclinical
- Heart
- Models, Cardiovascular
- Myocardial Infarction
- Organoids