Using the Mouse to Model Human Diseases: Cognitive Impairment in Systemic Lupus Erythematosus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32295852.
- Also identified by DOI 10.3899/jrheum.200410 and PMC identifier 11207199.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this 2020 Dunlop-Dottridge Lecture, the authors discuss cognitive impairment (CI), one of the most prevalent neuropsychiatric syndromes in systemic lupus erythematosus (SLE). Patients often report CI as the most bothersome disease-related manifestation, with a great effect on their quality of life. Nevertheless, studies focusing on CI remain scarce and no effective targeted therapy has been identified. We herein present murine models of CI in SLE with insights into the pathogenesis of this condition as well as the role of the renin angiotensin system in microglial activation. We will discuss the role of neuroimaging as a useful objective assessment tool, describing our experience in previous and ongoing clinical trials of CI in patients with SLE.
Medical subject headings
- Cognitive Dysfunction
- Lupus Erythematosus, Systemic
- Lupus Vasculitis, Central Nervous System