SnapShot: Cancer-Associated Fibroblasts.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32302576.
- Also identified by DOI 10.1016/j.cell.2020.03.013.
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Abstract
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions. This SnapShot summarizes the origins of CAFs, their diverse functions, and how this relates to heterogeneity within the population. The suitability of targeting CAFs therapeutically is also discussed.
Medical subject headings
- Cancer-Associated Fibroblasts
- Tumor Microenvironment