Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32312978.
- Also identified by DOI 10.1038/s41467-020-15700-3 and PMC identifier 7171100.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.
Medical subject headings
- Arthritis, Rheumatoid
- Biomarkers
- Scavenger Receptors, Class A