Assessment of expression of podoplanin in odontogenic tumors and cysts-An immunohistochemical study.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 32318424.
- Also identified by DOI 10.4103/jfmpc.jfmpc_1092_19 and PMC identifier 7114001.
- Licence recorded as CC BY-NC-SA.
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Abstract
The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts. It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous cysts (DC), 8 cases of radicular cysts (RC) and 8 dental follicles (DF) as controls which were immunohistochemically evaluated using an antibody against podoplanin. Immunostaining intensity, % of PPC and total score of ameloblastoma was higher than DC and DF but less than KCOT (t- 1.48). When DC was compared with KCOT and RC, the podoplanin expression was significantly higher with DC (<i>P</i> < 0.05). The podoplanin expression was comparatively higher with KCOT as compared to RC and DC. OT (t-4.40) revealed higher podoplanin expression as compared to OC and DF (t-5.54). There was significantly higher expression of podoplanin in cases of ameloblastoma and KCOT as compared to the RC, DC and DF. Podoplanin may be considered as a useful marker to delineate the aggressiveness of ameloblastoma and KCOT.