The tripeptide GHG as an unexpected hydrogelator triggered by imidazole deprotonation.
basic_science · Level V
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- Record sourced from PubMed, PMID 32322858.
- Also identified by DOI 10.1039/d0sm00224k.
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Abstract
The tripeptide glycyl-histidyl-glycine (GHG) self-assembles into long, crystalline fibrils forming a strong hydrogel (G'∼ 50 kPa) above a critical concentration of 40 mM upon the deprotonation of its imidazole group. Spectroscopic data reveal a mixture of helically twisted β-sheets and monomers to coexist in the gel phase.
Medical subject headings
- Hydrogels
- Imidazoles
- Oligopeptides