A Double-Layered Microneedle Platform Fabricated through Frozen Spray-Coating.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32323491.
- Also identified by DOI 10.1002/adhm.202000147.
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Abstract
This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).
Medical subject headings
- Drug Delivery Systems
- Needles