Novel strategy for septic acute kidney injury rescue: maintenance of the tubular integrity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32331593.
- Also identified by DOI 10.1016/j.kint.2019.12.024.
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Abstract
Fluid resuscitation for oliguria rescue in septic acute kidney injury (AKI) has limited success. By examination of the proximal tubular integrity, Nakano et al. identified paracellular renal filtrate leakage in proximal tubules after lipopolysaccharide induced tight junction disruption to contribute to oliguria. Suppression of lipopolysaccharide injury to proximal tubules by Toll-like receptor 4 knockout significantly ameliorated the oliguria and renal function loss in septic AKI. This commentary discusses the new therapeutic strategy for septic AKI rescue by proximal tubular integrity protection and the potential impact of tight junction injury in all AKI conditions.
Medical subject headings
- Acute Kidney Injury
- Toll-Like Receptor 4