Syndecan-4: major player or innocent bystander of the endothelial glycocalyx?
Level V
Where this comes from
- Record sourced from PubMed, PMID 32331597.
- Also identified by DOI 10.1016/j.kint.2020.01.040 and PMC identifier 8092442.
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Abstract
Glycocalyces are the pericellular coat of glycoproteins, glycolipids, and proteoglycans. Yet the exploration of glycocalyx function is still ongoing because of the availability of investigative tools capable of discerning the function of one component without inflicting collateral changes in the organization/function of other constituents. The current report by Ramnath et al. explores the function of one family of molecules, the syndecans, as potential regulators of endothelial cell glycocalyx thickness in normal and diabetic glomeruli.
Medical subject headings
- Diabetes Mellitus
- Diabetic Nephropathies