The Secret Life of lncRNAs: Conserved, yet Not Conserved.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32359433.
- Also identified by DOI 10.1016/j.cell.2020.04.012.
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Abstract
Guo and colleagues discover a new layer of complexity to the lncRNA evolution where positionally conserved lncRNAs in human ESCs are broadly spliced and exported to the cytoplasm contrary to their mouse counterpart that are predominantly unspliced and nuclear retained. Distinct processing leads to species-specific lncRNA function in pluripotency maintenance.
Medical subject headings
- RNA, Long Noncoding