Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32359434.
- Also identified by DOI 10.1016/j.cell.2020.04.005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlike most tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins." Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.
Medical subject headings
- Neoplasms
- Protein Phosphatase 2