Role of MPR as an Early Signal for Efficacy in Neoadjuvant Studies.

Blakely, Collin M; McCoach, Caroline E · Clin Cancer Res · 2020

editorial · Level V

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Abstract

Overall survival and disease-free survival have been the gold standard primary endpoints for neoadjuvant clinical trials. Major pathologic response is a clinically proven surrogate of efficacy and when used as the primary endpoint, can allow for more efficient evaluation of drugs in the neoadjuvant setting.<i>See related article by Cascone et al., p. 3525</i>.

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