A human monoclonal antibody blocking SARS-CoV-2 infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32366817.
- Also identified by DOI 10.1038/s41467-020-16256-y and PMC identifier 7198537.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
Medical subject headings
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibodies, Viral
- Betacoronavirus
- Coronavirus Infections
- Pandemics
- Pneumonia, Viral