From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 32375060.
- Also identified by DOI 10.1016/j.cmet.2020.04.012.
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Abstract
Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlations indicate β cell compensation in type 2 diabetes.
Medical subject headings
- Diabetes Mellitus, Type 2
- Insulin-Secreting Cells