T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019.
Where this comes from
- Record sourced from PubMed, PMID 32379887.
- Also identified by DOI 10.1093/infdis/jiaa252 and PMC identifier 7239156.
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Abstract
This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
Medical subject headings
- Betacoronavirus
- Clinical Laboratory Techniques
- Coronavirus Infections
- Lymphocyte Count
- Pneumonia, Viral
- T-Lymphocyte Subsets