Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32382733.
- Also identified by DOI 10.1093/cid/ciaa546 and PMC identifier 7454417.
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Abstract
On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
Medical subject headings
- Chloroquine
- Cytokines