Can a Cell Put Its Arms around a Memory?

Knudsen, Teresa E; Brickman, Joshua M · Cell Stem Cell · 2020

editorial · Level V

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Abstract

Johnny Thunders once wrote, "You can't put your arms around a memory…" and the song continues, "don't try." Yet, when complex morphogenetic movements accompany differentiation, the cellular memory of signaling becomes essential. In this issue of Cell Stem Cell, Gunne-Braden et al. (2020) report a network wrapping its arms around the memory of BMP signaling, a phenomenon known as hysteresis.

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