Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32386550.
- Also identified by DOI 10.1016/j.stem.2020.04.011.
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Abstract
In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby resulting in intestinal stem cell depletion and Wnt-uncoupled progenitor expansion.
Medical subject headings
- Cell Cycle Proteins
- Phosphoproteins