Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis.

Neumann, Bjoern; Foerster, Sarah; Zhao, Chao; Bodini, Benedetta; Reich, Daniel S; Bergles, Dwight E; Káradóttir, Ragnhildur Thóra; Lubetzki, Catherine et al. · Cell Stem Cell · 2020

basic_science · Level V

Where this comes from

Abstract

Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

Medical subject headings