High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32386554.
- Also identified by DOI 10.1016/j.stem.2020.04.004 and PMC identifier 7262396.
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Abstract
Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture and human-mouse chimeric brain modeling systems developed using human pluripotent stem cells help us understand the complex properties of human microglia.
Medical subject headings
- Induced Pluripotent Stem Cells
- Pluripotent Stem Cells