Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 32398875.
- Also identified by DOI 10.1038/s41591-020-0901-9.
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Abstract
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8<sup>+</sup> T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
Medical subject headings
- Betacoronavirus
- Coronavirus Infections
- Pneumonia, Viral
- Single-Cell Analysis