A serological assay to detect SARS-CoV-2 seroconversion in humans.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32398876.
- Also identified by DOI 10.1038/s41591-020-0913-5 and PMC identifier 8183627.
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Abstract
Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection.
Medical subject headings
- Betacoronavirus
- Clinical Laboratory Techniques
- Coronavirus Infections
- Pneumonia, Viral
- Seroconversion