CD4<sup>+</sup> T Cells at the Center of Inflammaging.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32402265.
- Also identified by DOI 10.1016/j.cmet.2020.04.016 and PMC identifier 7217078.
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Abstract
Bharath et al., 2020 report that CD4+ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or "inflammaging." Of note, the antiaging drug metformin reverses this autophagy defect and rejuvenates CD4+ T cell function.
Medical subject headings
- Metformin