An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 32407466.
- Also identified by DOI 10.1093/cid/ciaa577 and PMC identifier 7239202.
- Licence recorded as CC BY-NC-ND.
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Abstract
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
Medical subject headings
- COVID-19
- Inflammation
- Killer Cells, Natural
- Perforin
- T-Lymphocytes, Cytotoxic