What Makes a Discovery Successful? The Story of Linda Buck and the Olfactory Receptors.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32413294.
- Also identified by DOI 10.1016/j.cell.2020.04.040.
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Abstract
In 1991, Buck and Axel published a landmark study in Cell for work that was awarded the 2004 Nobel Prize. The identification of the olfactory receptors as the largest family of GPCRs catapulted olfaction into mainstream neurobiology. This BenchMark revisits Buck's experimental innovation and its surprising success at the time.
Medical subject headings
- Receptors, Odorant
- Smell