Feeling Stressed? Piezo1-Mediated Loss of Heterochromatin Buys Time for Long-Term Adaptation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32413297.
- Also identified by DOI 10.1016/j.cell.2020.04.041.
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Abstract
Skin and other epithelial cell layers are frequently subjected to extensive deformations, yet sustain such mechanical stress without damage. In this issue of Cell, Nava and colleagues show that stretch induces rapid loss of heterochromatin that leads to transient softening of the nucleus, which, together with long-term cytoskeletal and supracellular rearrangements, protects nuclei from DNA damage.
Medical subject headings
- Heterochromatin
- Ion Channels