Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32416070.
- Also identified by DOI 10.1016/j.cell.2020.04.026 and PMC identifier 7227586.
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Abstract
Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
Medical subject headings
- Betacoronavirus
- Coronavirus Infections
- Pneumonia, Viral
- RNA Viruses