Effects of different chemical groups on behaviors of bladder cancer cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32418363.
- Also identified by DOI 10.1002/jbm.a.36999.
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Abstract
Chemical groups of microenvironment play an important role in the adhesion, proliferation, and apoptosis of tumor cells. The different chemical groups (CH<sub>3</sub> , OH, COOH) were grafted on the surfaces with the same density by self-assembly monolayer (SAM) technique to introduce the influence of different microenvironments of the human bladder cancer (5637) cells. The results indicated that the 5637 cells on COOH surface exhibited the lowest proliferation rate and the highest apoptosis rate on the first and fifth day because of negative charge and polarity of the COOH group, which might help optimize biomedicine materials and find new methods to treat bladder cancer.
Medical subject headings
- Apoptosis
- Biocompatible Materials
- Cell Proliferation
- Tumor Microenvironment
- Urinary Bladder Neoplasms