Elasticizing tissues for reversible shape transformation and accelerated molecular labeling.
basic_science · Level V
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- Record sourced from PubMed, PMID 32424271.
- Also identified by DOI 10.1038/s41592-020-0823-y and PMC identifier 8056749.
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Abstract
We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.
Medical subject headings
- Hydrogels
- Staining and Labeling
- Tissue Engineering