Influence of Storage Conditions on SARS-CoV-2 Nucleic Acid Detection in Throat Swabs.
Where this comes from
- Record sourced from PubMed, PMID 32427340.
- Also identified by DOI 10.1093/infdis/jiaa272 and PMC identifier 7313924.
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Abstract
The detection of SARS-CoV-2 infection is the premise of quarantine. In many countries or areas, samples need to be shipped or inactivated before SARS-CoV-2 testing. In this study, we checked the influence of sample storage conditions on SARS-CoV-2 nucleic acid testing results, including sample inactivation time, storage temperature, and storage time. All of these conditions caused an increase in the cycle threshold values of the nucleic acid tests and led to the misclassification of at least 10.2% of positive cases as negative or suspected. The results highlight the importance of immediate testing of samples for SARS-CoV-2 nucleic acid detection.
Medical subject headings
- Betacoronavirus
- Clinical Laboratory Techniques
- Coronavirus Infections
- Pharynx
- Pneumonia, Viral
- Specimen Handling