Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight.
Where this comes from
- Record sourced from PubMed, PMID 32428380.
- Also identified by DOI 10.1002/oby.22907 and PMC identifier 7276828.
- Licence recorded as CC BY-NC-ND.
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Abstract
Mortality from coronavirus disease 2019 (COVID-19) is increased in patients with chronic obstructive pulmonary disease (COPD). Furthermore, higher BMI is related to severe disease. Severe acute respiratory syndrome coronavirus 2 utilizes angiotensin converting enzyme 2 (ACE2) to gain cellular entry. Whether ACE2 bronchial epithelial expression is increased in COPD patients who have overweight compared with those who do not was investigated by RNA sequencing. Increased ACE2 expression was observed in patients with COPD with overweight (mean BMI, 29 kg/m<sup>2</sup> ) compared with those without overweight (mean BMI, 21 kg/m<sup>2</sup> ) (P = 0.004). Increased ACE2 expression may cause increased severe acute respiratory syndrome coronavirus 2 infection of the respiratory tract. Overweight COPD patients may be at greater risk for developing severe COVID-19.
Medical subject headings
- Bronchi
- Epithelium
- Overweight
- Peptidyl-Dipeptidase A
- Pulmonary Disease, Chronic Obstructive