Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32435791.
- Also identified by DOI 10.1093/cid/ciaa623 and PMC identifier 7314136.
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Abstract
Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.
Medical subject headings
- Antiviral Agents
- Hydroxychloroquine
- COVID-19 Drug Treatment