Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype.
Where this comes from
- Record sourced from PubMed, PMID 32439433.
- Also identified by DOI 10.1016/j.jaci.2020.04.056 and PMC identifier 7674263.
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Abstract
All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative <i>ex vivo</i> responses to dalbavancin however two showed cross-reactivity to teicoplanin and telavancin. Adjunctive diagnostic testing should be considered to detect potential cross-reactivity amongst glycopeptides.
Medical subject headings
- Aminoglycosides
- Drug Hypersensitivity Syndrome
- HLA-A Antigens
- Haplotypes
- Lipoglycopeptides
- Teicoplanin
- Vancomycin