T<sub>RM</sub> integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32439709.
- Also identified by DOI 10.1073/pnas.1915681117 and PMC identifier 7275699.
- Licence recorded as CC BY-NC-ND.
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Abstract
Tissue-resident memory CD8 T (T<sub>RM</sub>) cells are a unique immune memory subset that develops and remains in peripheral tissues at the site of infection, providing future host resistance upon reexposure to that pathogen. In the pulmonary system, T<sub>RM</sub> are identified through S1P antagonist CD69 and expression of integrins CD103/β7 and CD49a/CD29(β1). Contrary to the established role of CD69 on CD8 T cells, the functions of CD103 and CD49a on this population are not well defined. This study examines the expression patterns and functions of CD103 and CD49a with a specific focus on their impact on T cell motility during influenza virus infection. We show that the T<sub>RM</sub> cell surface phenotype develops by 2 wk postinfection, with the majority of the population expressing CD49a and a subset that is also positive for CD103. Despite a previously established role in retaining T<sub>RM</sub> in peripheral tissues, CD49a facilitates locomotion of virus-specific CD8 T cells, both in vitro and in vivo. These results demonstrate that CD49a may contribute to local surveillance mechanisms of the T<sub>RM</sub> population.
Medical subject headings
- Antigens, CD
- Influenza A Virus, H3N2 Subtype
- Influenza, Human
- Integrin alpha Chains
- Integrin alpha1