Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32443148.
- Also identified by DOI 10.1093/infdis/jiaa270 and PMC identifier 7751567.
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Abstract
Historical data regarding time to viral rebound following analytical treatment interruption (ATI) have been used to determine therapeutic efficacy in HIV cure trials; however, such data were collected from studies conducted a decade or more ago and included participants receiving older antiretroviral therapy (ART) regimens with infrequent virologic monitoring. We conducted a study of 22 HIV-infected participants receiving modern ART to determine the kinetics of plasma viral rebound following ATI. Our data suggest that modern ART does not alter kinetics of viral rebound when compared to previous regimens and that immunologic interventions may be necessary to achieve ART-free virologic remission. Clinical Trials Registration ClinicaTrials.gov identifier: NCT03225118.
Medical subject headings
- Anti-Retroviral Agents
- HIV Infections
- Plasma