Accumulation of protein-bound uremic toxins: the kidney remains the leading culprit in the gut-liver-kidney axis.
Where this comes from
- Record sourced from PubMed, PMID 32444090.
- Also identified by DOI 10.1016/j.kint.2020.02.026.
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Abstract
Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more PBUTs than do those from healthy controls and that the accumulation of PBUTs, as CKD progresses, is mainly due to their reduced renal elimination by glomerular filtration and tubular secretion. This work underlines the importance of studying the metabolism of PBUTs along the diet-gut-liver-kidney axis.
Medical subject headings
- Renal Insufficiency, Chronic
- Toxins, Biological
- Uremia