Photothermal modulation of human stem cells using light-responsive 2D nanomaterials.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32461372.
- Also identified by DOI 10.1073/pnas.1914345117 and PMC identifier 7306823.
- Licence recorded as CC BY-NC-ND.
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Abstract
Two-dimensional (2D) molybdenum disulfide (MoS<sub>2</sub>) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS<sub>2</sub> to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS<sub>2</sub> and NIR stimulation of MoS<sub>2</sub> with human stem cells is investigated using whole-transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence of MoS<sub>2</sub> and NIR stimulation of MoS<sub>2</sub> on integrins, cellular migration, and wound healing. The combination of MoS<sub>2</sub> and NIR light may provide new approaches to regulate and direct these cellular functions for the purposes of regenerative medicine as well as cancer therapy.
Medical subject headings
- Disulfides
- Mesenchymal Stem Cells
- Molybdenum
- Nanostructures