Biasing Neurotensin Receptor Signaling to Arrest Psychostimulant Abuse.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32470394.
- Also identified by DOI 10.1016/j.cell.2020.05.009.
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Abstract
Biasing G protein-coupled receptor signaling with ligands that promote select pathways is emerging as a powerful approach for therapeutic drug discovery. In this issue of Cell, Slosky et al. report a β-arrestin-biased neurotensin receptor ligand that may curtail drug abuse without the side effects induced by G protein signaling.
Medical subject headings
- Behavior, Addictive
- Receptors, Neurotensin