Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes.
Level II
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- Record sourced from PubMed, PMID 32471909.
- Also identified by DOI 10.2337/dc20-0171 and PMC identifier 7372055.
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Abstract
To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (<i>P</i> = 0.014) were observed. Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.
Medical subject headings
- Diabetes Mellitus, Type 1
- Hyperglycemia
- Memory, Short-Term
- Spatial Memory