Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell-Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis.

McCafferty, Conor; Busuttil-Crellin, Xavier; Cai, Tengyi; Monagle, Paul; Goldenberg, Neil A; Ignjatovic, Vera · J Pediatr · 2020

other · Level V

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Abstract

This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.

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