Macromolecular modeling and design in Rosetta: recent methods and frameworks.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32483333.
- Also identified by DOI 10.1038/s41592-020-0848-2 and PMC identifier 7603796.
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Abstract
The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability. Rosetta is available at http://www.rosettacommons.org.
Medical subject headings
- Macromolecular Substances
- Models, Molecular
- Proteins
- Software