On the coupling of mechanics with bioelectricity and its role in morphogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32486953.
- Also identified by DOI 10.1098/rsif.2020.0177 and PMC identifier 7328399.
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Abstract
The role of endogenous bioelectricity in morphogenesis has recently been explored through the finite volume-based code <i>BioElectric Tissue Simulation Engine</i>. We extend this platform to electrostatic and osmotic forces due to bioelectrical ion fluxes, causing cell cluster deformation. We further account for mechanosensitive ion channels, which, gated by membrane tension, modulate ion fluxes and, ultimately, bioelectrical forces. We illustrate the potentialities of this combined model of actuation and sensing with reference to cancer progression, osmoregulation, symmetry breaking and long-range signalling. This suggests control strategies for the manipulation of cell networks <i>in vivo</i>.
Medical subject headings
- Electrophysiological Phenomena
- Ion Channels