Of Mice and Men: NAD<sup>+</sup> Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients.
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- Record sourced from PubMed, PMID 32492387.
- Also identified by DOI 10.1016/j.cmet.2020.05.013.
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Abstract
In this issue of Cell Metabolism, Pirinen et al. (2020) show that disruption in NAD+ homeostasis is a key component of the pathogenesis of mitochondrial myopathy in humans that can be targeted by the administration of the NAD+ precursor niacin, identifying NAD+ boosting as a potential treatment for this devastating disease.
Medical subject headings
- Mitochondrial Myopathies
- Niacin