Pseudomonas Persists by Feeding off Itaconate.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 32492389.
- Also identified by DOI 10.1016/j.cmet.2020.05.005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Itaconate is an immunometabolite with anti-inflammatory and anti-microbial properties. Riquelme et al. (2020) demonstrate that pathogenic Pseudomonas aeruginosa drives itaconate production by macrophages, which it then uses as a carbon source for biofilm formation, allowing it to persist during infection and suppress inflammation.
Medical subject headings
- Pseudomonas
- Pseudomonas aeruginosa